Estrogen receptor ( er ) , an important transcription factor belonging to the nuclear receptor superfamily , plays a key role in reproductive , cardiovascular and central nervous systems and bone tissue 摘要雌激素受体属于核受体超家族成员，是一类重要的核转录因子，它在生殖系统、骨组织、心血管和中枢神经系统中发挥著重要的生理作用，是治疗骨质疏松和乳腺癌的重要药物作用靶标。
Here we show that 27 - hydroxycholesterol ( 27hc ) , an abundant cholesterol metabolite that is elevated with hypercholesterolemia and found in atherosclerotic lesions , is a competitive antagonist of estrogen receptor action in the vasculature 在此我们发现27 -羟基胆甾醇( 27hc )是一种含量丰富的胆固醇代谢产物，它的过量引起高胆固醇血症并存于粥样硬化病变中，在血管中是雌激素受体竞争性拮抗剂。
Since evidence shows anti - estrogen drugs will fail in a many patients with estrogen - receptor - positive breast cancer , says knudsen , our research suggests that physicians should examine both estrogen receptor status and rb tumor suppressor status during the initial diagnosis , in order to prescribe the most effective therapy for that specific patient ' s cancer . 证据表明，抗雌激素药物对雌激素受体阳性乳癌将失效，我们的研究提示，为了给那些特殊癌症患者制定最有效的治疗方法，医生应该在开始诊断时检测雌激素受体和rb抑癌基因状况。
Since eidence shows anti - estrogen drugs will fail in a many patients with estrogen - receptor - positie breast cancer , says knudsen , our research suggests that physicians should examine both estrogen receptor status and rb tumor suppressor status during the initial diagnosis , in order to prescribe the most effectie therapy for that specific patient ' s cancer . 证据表明，抗雌激素* *物对雌激素受体阳性乳癌将失效，我们的研究提示，为了给那些特殊癌症患者制定最有效的治疗方法，医生应该在开始诊断时检测雌激素受体和rb抑癌基因状况。
